Endocrine Abstracts

We describe a case of subacute thyroiditis in a psoriatic patient treated with Adalimumab, with a very good clinical evolution with nonsteroidal anti-inflamatory medication.Tumor necrosis factor alpha (TNF-α) is a pleiotropic cytokine produced by a variety of cells, comprehending T lymphocytes. TNF-α mediates its effects through two receptors, known as p55 (TNF-R1), and p75 (TNF-R2). TNF-α plays a primary role in both the induction and the...

Background: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015-2017 with the aim to assess the incidence and impact of intraoperative features that may predispose to postoperative hypoparathyroidism (PoSH).Results: 171 (30.97%) pati...

Introduction: Hyperthyroidism and thyrotoxicosis can have multiple etiologies, varying from the most frequent described in clinical practice (Graves disease, toxic nodular goiter, thyroiditis) to very rare causes such as anaplastic thyroid cancer, thyroid lymphoma, amyloidosis or even secondary malignancy of the thyroid gland.Case report: A 53 year old man presented to our department for progressive goiter enlargement in the last two months which was acc...

Introduction: We report a case of a pituitary insufficiency apparently resistant to treatment.Case report: A 74 year old patient was admitted through the ER in our department for a recently discovered pituitary macroadenoma. His general condition was poor in spite of the initiation of corticotherapy. Evaluation: Smoker, with no significant medical history, the BP: 100/60 mmHg, no orthostatic hypotension, disoriented, confused, with moderately altered gen...

Abnormalities of growth are one of the most common reasons for the paediatric–endocrinology consults. It’s an obvious manifestation with countless possible causes behind, and sometimes we can have unexpected diagnosis.Case presentation: we investigated the case of a 4 years old girl, born at term, naturally, SGA: birth weight=1950 g, who presented in the Endocrinology Department for short stature. Clinical evaluation: 89.5 cm (−4 DS), 11 ...

Introduction: There are many side effects caused by mitotane and several are registered at drug levels lower than therapeutical doses.Aim: We observed the mitotane side effects in patients treated for adrenal cancer.Materials and methods: This is a retrospective study in adrenal tumors.Results: Out of 56 patients included in a database with adrenal tumors, we found eight patients (14.25%) with adrenal cancer ...

Introduction: Exogenous Cushing’s syndrome is a challenging diagnosis in non-compliant patients or in cases with difficult anamnesis, while the access to self medication is relatively open.Aim: We present a young female case presenting with tertiary adrenal insufficiency.Case report: S.C., 40 years old has progressively weight gain of 30 kilos since the last year. The Body Mass Index is 40 kg/m2, with androgen redis...

Introduction: The risk for the development of germ cell tumors is hard to predict in patients with disorders of sex development (DSD) and their optimal management has been a continuous matter of debate. The risk varies between unknown and 40–60% in Denys-Drash/Frasier syndrome. This malignant potential opposes itself firmly to the recent interest in a more conservative approach regarding gonadectomy.Case presentation: We present the case of a 20-yea...

I fine-needle aspiration (FNA) is the gold standard in thyroid nodules management, but it is less common in the evaluation of parathyroid nodules. When imagery fails to localize a parathyroid adenoma, morphological and functional investigations, like FNA of the suspected area and scintigraphy may be useful. We present the case of a 58 years-old woman, menopaused at 47 years, who consulted for lombalgia. Vertebral DXA confirmed osteoporosis (Tscore −3.8). She was not trea...

Background: Denosumab (DMAb) and zoledronic acid (ZA) are potent, anti-resorptive agents used to treat patients with osteoporosis. It has been suggested that they increase parathyroid hormone (PTH) levels in response to their antiresorptive effect, and that PTH elevation might be responsible for DMAb modeling actions on bone. The timeline and magnitude of PTH elevation post-DMAb and ZA has not been characterized in a large patient population.Objective: T...